If you like us, please share us on social media.
The latest UCD Hyperlibrary newsletter is now complete, check it out.
Copyright (c) 2006-2014 MindTouch Inc.
This file and accompanying files are licensed under the MindTouch Master Subscription Agreement (MSA).
At any time, you shall not, directly or indirectly: (i) sublicense, resell, rent, lease, distribute, market, commercialize or otherwise transfer rights or usage to: (a) the Software, (b) any modified version or derivative work of the Software created by you or for you, or (c) MindTouch Open Source (which includes all non-supported versions of MindTouch-developed software), for any purpose including timesharing or service bureau purposes; (ii) remove or alter any copyright, trademark or proprietary notice in the Software; (iii) transfer, use or export the Software in violation of any applicable laws or regulations of any government or governmental agency; (iv) use or run on any of your hardware, or have deployed for use, any production version of MindTouch Open Source; (v) use any of the Support Services, Error corrections, Updates or Upgrades, for the MindTouch Open Source software or for any Server for which Support Services are not then purchased as provided hereunder; or (vi) reverse engineer, decompile or modify any encrypted or encoded portion of the Software.
A complete copy of the MSA is available at http://www.mindtouch.com/msa
Biochemistry: Understanding Living Organisms At the Molecular Level
A major goal of biochemistry is to study the cellular processes of living organisms and how these processes relate to the functioning of the organism. Research in the area of biochemistry has been extremely successful over the last century; we now know the atoms and biomolecules that make up living organisms, the central dogma around which biological information is transferred and how this information results in a greater understanding of ourselves and the world in which we live. One of the most important results from research in biochemistry is that all organisms are uniform at the molecular level and the diversity we see today is a result of evolution.
What biomolecules make up living organisms?
List of biomolecules in E. coli
|Biomolecules in E. Coli||% by Weight||Numbers of Types|
|Amino Acids*||0.4%||20 [including 120 a.a. involved in non protein function|
|Nucleic Acids||RNA= 6%, DNA=1%||RNA= 1000, DNA=1|
|Various (lignins, isoprenoids)|
Highlighted in this table are four major classes of biomolecules. The *polymers of life include proteins, polysaccharides, nucleic acids, and lipids and their corresponding *monomers, amino acids, sugars, nucleotides, and free lipids, respectively. There are also combinations of monomers and polymers such as glycolipids, lipoproteins, etc.
Handedness (Chirality), Sense, Directionality
Covalent Bonds, Hydrogen Bonds, Ionic Bonds, Van Der Waals Forces, Hydrophobic Interactions
Stability and Flexibility, Structural Complementarity, Recognition, Complexes (especially Van Der Waals), Limited Environmental Tolerances
implied in any changes in the forces/bonds that are holding molecules together- stability
synthesis, polymerization of biomolecules (metabolism) imply energy transformations
Decay, turnover (related to entropy)
Other transformations (e.g., light ---> chemical instability)
Implied by synthesis, decay—chemical reactions, limited by activation energy structural basis of enzyme catalysis, measurement, and organization of catalyzed sequential reactions are the major foci of the course
Course considers biomolecules—proteins, sugars, lipids—and transformations among them (metabolism), with emphasis on proteins (enzymes) and their role in catalyzing metabolic reactions
Energy is important: distinguish between binding energy, energy transformations, etc. (nucleic acids are treated in BIS 101; complex cell activities in BIS 104)